They are two-phase systems typically containing hydrophilic ingredient in an aqueous phase and lipophilic ingredients in an oil phase. In order for topical emulsions to function effectively they require certain functional excipients.
BASF offers an unparalleled portfolio of excipients for topical formulations enabling you to create the ideal skin delivery solution for your cream or emulsion. We are committed to maintaining the highest level of quality. At the same time, we have focused on improving the mildness of formulations. And by extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance.
Our range of solubilizers and penetration enhancers support effective delivery of the target API — the number-one priority when designing any dermatological product. Lipophilic fluids that can a solubilize lipophilic APIs, b form films on the skin that provide a barrier to water loss, c provide pleasing sensorial cues during and after product application.
Amphiphilic molecules that catalyze and stabilize the homogeneous blending and dispersing of one phase into another e. These are most commonly anionic or non-ionic in nature. Typically waxes or polymers that build colloidal structures, networks or microstructures that increase the viscosity of emulsions thereby improving cream emulsion stability and also allowing the user to effectively transfer the product from the primary package to the location of application.
Both lipophilic and hydrophilic fluids may be used to enhance the solubilization of APIs, prevent crystallization or stabilize crystal habits and polymorphs in topical semi-solid formulations. The delivery of APIs through the stratum corneum and into the skin can be accelerated by a variety of different materials.
The choice of the right material is determined by the physico-chemical characteristics of the API e. A medium spreading emollient with penetration enhancement properties, and a potential solvent for lipophilic solvents.
A medium spreading non-ester emollient which is stable against acid and base hydrolysis and provides good skin penetration.
A non-ionic emulsifier with good sensory properties; stable with acidic, basic and ionic excipients. A self-emulsifying mixture of emulsifier and consistency factors for simplified preparation of skin cream base. A polymeric multi-talent suitable for a large variety of applications, i. It is commonly also used as viscosity regulator for oil-in-water emulsions and as a pH independent sustained release agent. It hardens suppository formulations and adjust their melting points.
Soluble copovidone widely used for instant release formulation and is suitable in hot-melt extrusion processes. BASFs rich portfolio of instant and modified release solutions offers an unprecedented range of functionality.
Benefits Extensive expertise and understanding of topical products Increased patient compliance through characterized sensorial effects High quality products for maximum mildness Innovative breakthroughs such as improved delivery systems Meets the highest regulatory and quality requirements.
Oils or Emollients Lipophilic fluids that can a solubilize lipophilic APIs, b form films on the skin that provide a barrier to water loss, c provide pleasing sensorial cues during and after product application.Topical agents are used locally, where the medicine is applied on the area being treated.
For example creams, ointment and lotions are applied topically on the skin. Eye drops are instilled directly into the eyes.
EMULGELS: A NOVEL FORMULATION APPROACH FOR TOPICAL DELIVERY OF HYDROPHOBIC DRUGS
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A number of factors contribute to this phenomenon, including lack of treatment efficacy and patient concerns regarding side effects, among others. At the forefront of barriers facing optimal patient adherence to topical treatment is choosing the ideal topical vehicle formulation. Medical professionals have demonstrated a lack of understanding with respect to the composition and nomenclature of the various topical formulations.
In this review, we clarify the properties and definitions of the following topical formulations: ointments, creams, lotions, topical solutions, topical suspensions, gels, foams, and sprays.
We also provide suggested areas of application for the aforementioned formulations and a succinct, patient-geared summary of their advantages and disadvantages. This review hopes to deliver a clear and concise practical summary of the most commonly encountered topical formulations for the treatment of cutaneous disease for medical professionals.
This will allow clinicians to provide their patients with accurate information to facilitate informed choice of topical formulation, which may serve to improve treatment adherence.Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv. Skip to search form Skip to main content You are currently offline.
Some features of the site may not work correctly. A unique feature of topical drug delivery is the direct accessibility of the skin as a target organ for diagnosis and treatment. Among the various groups of semisolid preparations, the use of gels has expanded both in cosmetics and in pharmaceutical preparations. Despite of several advantages of gels there is a limitation in delivery of hydrophobic drug moiety. This limitation can be overcome by the use of novel topical drug delivery i.
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Formulation and evalaution of chlorzoxazone transdermal emulgel by using natural penetration enhancer A. SusmithaGanesh kumar Gudas Stability of amorphous forms of roxithromycin when encapsulated in liposomes Michelene Swart Chemistry The use of apricot oil emulsions for the transdermal delivery of selected statins Suzanne Marais Medicine Transdermal delivery of selected statins formulated in apricot kernel oil emulsions Susanna Marina Maree Chemistry Preparation and evaluation of an Emulgel of Hydroxyzine hydrochloride P.
Kotra LakshmiK. MounikaKalyani Kalyani Chemistry AsharaKetan V.Pharmaceutical chemistry is a specialty of pharmacy that deals with the chemical properties of pharmaceuticals in the broadest sense.
The analysis detection of drugs and pharmaceuticals as well as the synthesis production of the drugs plays a special role. Areas closely related to pharmaceutical chemistry are medicinal chemistry, pharmacology and toxicology.
The basis of pharmaceutical chemistry is organic chemistry as well as branches of inorganic chemistry. Acta Pharmaceutica AP publishes review articles, original research papers, preliminary and short communications dealing with pharmacy and related fields. Archiv der Pharmazie Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry.
Asian Journal of Pharmaceutical Sciences AJPS provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to all aspects of pharmaceutics. Biochemical Pharmacology Dhaka University Journal of Pharmaceutical Sciences Die Pharmazie European Journal of Pharmaceutical Sciences Indian Journal of Pharmaceutical Sciences International Journal of Pharmaceutical Compounding IJPC is the only publication that covers pharmaceutical compounding topics relevant and necessary to empower pharmacists to meet the needs of today's patients.
A Guide to Topical Vehicle Formulations.
Journal of Labelled Compounds and Radiopharmaceuticals Journal of Pharmaceutical and Biomedical Analysis Journal of Pharmaceutical Innovation Journal of Pharmaceutical Science The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals, including crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology, and targeted drug delivery.
Journal of Pharmaceutical Sciences The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals, including crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology, and targeted drug delivery.
Pharmaceutical Chemistry Journal Pharmaceutical StatisticsPharmaceutical Chemistry. Edited by L. Marcel Dekker, Inc. Download PDF.
Recommend Documents. A short pharmaceutical chemistry. Practical Pharmaceutical Chemistry. Medicinal and Pharmaceutical Chemistry.
Pharmaceutical and medical chemistry. Modern Inorganic Pharmaceutical Chemistry. Practical Pharmaceutical Chemistry, 4th edn. This text is a contributive volume with 13 chapters by 13 different authors. A detailed examination of the book supports this contention. The introductory chapter introduces the concept of quality control and sampling; in addition, the subjects of mass and volume determination and laboratory techniques which are usually treated in a first course in analysis are reviewed.
Although the calculation of titration curve points and titration of mixtures is treated very well, some twenty pages are used t o review equilibria topics which should be familiar t o students at this level or at least they can review on their own. The chapter dealing with precipitation, complex formation, and oxidation-reduction methods is an extensive consideration of the very numerous analyses of this type with some theoretical comment.
Similarly, the chapter on acidimetry and alkalimetry deals with rudimentary analytical topics, e. This type of material would be better presented in a reference rather than a textbook. Nonaqueous titrimetry is presented a t too practical a level without use of topics such as glacial acetic acid equilibria.
The chapter on complexometry is good, but rigorous calculations involving complex equilibria are not adequately developed.
Although the chapter on alkaloidal assay is interesting, it fails, e.
However, the use of tables to summarize the many analytical methods is excellent. The miscellaneous methods chapter is very good in its treatment of topics such as the Karl Fischer titration, gas analysis, and nitrosation. Likewise, the section on ion-exchange separations is very well done. Enough theory is presented to permit the student to make simple calculations describing column behavior. Column, thin-layer, and paper chromatography are treated well in a single chapter but certain organizational lapses are disturbing, viz.
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